Thiazolidinediones mechanism of action Thiazolidinediones (TZDs) are a class of medications that can help manage Type 2 diabetes through their unique mechanism of action. Jan 23, 2024 · Thiazolidinedione has been used successfully by medicinal chemists all over the world in the development of potent antidiabetic derivatives. Besides metabolic activities Jan 1, 2022 · The growing understanding of the mechanism of action of these agents together with advances in the pathophysiology of chronic metabolic disease offers a new approach to treat chronic conditions, such as type 2 diabetes, fatty liver disease, and their common organ and vascular sequelae. Although discovered more than two decades ago, it was not until the mid-1990s that their molecular mechanism of action was elucidated. The clofibrate analog, ciglitazone (ASS-3878, Takeda pharmaceuticals, Japan), found to have a hypoglycemic effect in 1982, is the prototype of TZDs class but not used as an antidiabetic drug because of hepatotoxicity. Aug 1, 2024 · Shakour et al. A. TZDs also increase adiponectin levels, decrease hepatic gluconeogenesis, and increase insulin-dependent glucose uptake in muscle and fat. The molecular evidence linking PPAR-γ activation and each of these mechanisms is discussed below. , 50 ( 2013 ) , pp. rwrqxe tkx ruxkii mdirlc tymdvr idy bbdmh oxt pgx pfm